Lutropin alfa
Luveris, Pergoveris (lutropin alfa) is a protein pharmaceutical. Lutropin alfa was first approved as Luveris on 2000-11-29. It is used to treat female infertility in the USA. It has been approved in Europe to treat female infertility and ovulation induction. The pharmaceutical is active against lutropin-choriogonadotropic hormone receptor.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| urogenital diseases | D000091642 |
| therapeutics | D013812 |
| investigative techniques | D008919 |
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| female infertility | EFO_0008560 | D007247 | N97 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
279 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Prostatic neoplasms | D011471 | — | C61 | 4 | 25 | 24 | 3 | 10 | 65 |
| Infertility | D007246 | HP_0000789 | — | 5 | 9 | 7 | 13 | 22 | 54 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 3 | 10 | 5 | 1 | 3 | 21 |
| Female infertility | D007247 | EFO_0008560 | N97 | 2 | 1 | 1 | 5 | 4 | 13 |
| Hypogonadism | D007006 | HP_0000044 | E23.0 | 1 | 2 | 1 | 2 | 2 | 8 |
| Ovulation induction | D010062 | — | — | — | 4 | 2 | 1 | — | 7 |
| Fertilization in vitro | D005307 | — | — | — | — | — | 4 | 1 | 5 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | 1 | 1 | 2 |
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | — | — | — | 1 | 1 | 2 |
| Hyperprolactinemia | D006966 | HP_0000870 | E22.1 | — | — | — | 1 | 1 | 2 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Adenocarcinoma | D000230 | — | — | — | 5 | 4 | — | — | 9 |
| Triple negative breast neoplasms | D064726 | — | — | — | 2 | 3 | — | — | 5 |
| Assisted reproductive techniques | D027724 | — | — | — | — | 2 | — | 1 | 3 |
| Castration-resistant prostatic neoplasms | D064129 | — | — | 2 | 2 | 1 | — | — | 3 |
| Precocious puberty | D011629 | — | E22.8 | — | 1 | 2 | — | — | 3 |
| Neoplasms | D009369 | — | C80 | — | 1 | 1 | — | — | 2 |
| Bone neoplasms | D001859 | EFO_0003820 | D16 | — | — | 1 | — | — | 1 |
| Fertility | D005298 | — | — | — | — | 1 | — | — | 1 |
| Pain | D010146 | EFO_0003843 | R52 | — | — | 1 | — | — | 1 |
| Fertility preservation | D059247 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Contraception | D003267 | — | — | 1 | 1 | — | — | 1 | 3 |
| Primary ovarian insufficiency | D016649 | EFO_0004266 | E28.3 | 1 | 1 | — | — | 1 | 2 |
| Growth disorders | D006130 | — | — | — | 1 | — | — | 1 | 2 |
| Male breast neoplasms | D018567 | — | — | — | 1 | — | — | — | 1 |
| Menorrhagia | D008595 | EFO_0003945 | N92.0 | — | 1 | — | — | — | 1 |
| Premature menopause | D008594 | HP_0008209 | E28.31 | 1 | 1 | — | — | — | 1 |
| Menopause | D008593 | EFO_0003922 | N95 | 1 | 1 | — | — | — | 1 |
| Hot flashes | D019584 | — | — | 1 | 1 | — | — | — | 1 |
| Urologic neoplasms | D014571 | — | C64-C68 | 1 | 1 | — | — | — | 1 |
| Dwarfism | D004392 | HP_0003510 | E34.31 | — | 1 | — | — | — | 1 |
Show 4 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Polycystic ovary syndrome | D011085 | EFO_0000660 | E28.2 | 5 | — | — | — | 3 | 8 |
| Hyperandrogenism | D017588 | — | — | 4 | — | — | — | 1 | 5 |
| Healthy volunteers/patients | — | — | — | 3 | — | — | — | 1 | 4 |
| Puberty | D011627 | EFO_0001382 | — | 3 | — | — | — | — | 3 |
| Endometriosis | D004715 | EFO_0001065 | N80 | 1 | — | — | — | 1 | 2 |
| Hemophilia a | D006467 | EFO_0007267 | D66 | 1 | — | — | — | — | 1 |
| Gynatresia | D006175 | EFO_1001335 | N85.6 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Male infertility | D007248 | EFO_0004248 | N46 | — | — | — | — | 2 | 2 |
| Autonomic nervous system diseases | D001342 | EFO_0009532 | G90 | — | — | — | — | 2 | 2 |
| Menstrual cycle | D008597 | — | — | — | — | — | — | 2 | 2 |
| Covid-19 | D000086382 | — | U07.1 | — | — | — | — | 2 | 2 |
| Preimplantation diagnosis | D019836 | — | — | — | — | — | — | 1 | 1 |
| Spinal cord injuries | D013119 | EFO_1001919 | — | — | — | — | — | 1 | 1 |
| Systemic scleroderma | D012595 | EFO_0000717 | M34 | — | — | — | — | 1 | 1 |
| Uterine inertia | D014593 | EFO_1001863 | O62.2 | — | — | — | — | 1 | 1 |
| Hematologic diseases | D006402 | EFO_0005803 | D75.9 | — | — | — | — | 1 | 1 |
| Thalassemia | D013789 | EFO_1001996 | D56 | — | — | — | — | 1 | 1 |
Show 22 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Lutropin alfa |
| INN | lutropin alfa |
| Description | Lutropin beta chain precursor (Luteinizing hormone beta subunit) (LSH-beta) |
| Classification | Protein |
| Drug class | tricyclic compounds; atropine derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201419 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | 3JGY52XJNA (ChemIDplus, GSRS) |
Target
Agency Approved
LHCGR
LHCGR
Organism
Homo sapiens
Gene name
LHCGR
Gene synonyms
LCGR, LGR2, LHRHR
NCBI Gene ID
Protein name
lutropin-choriogonadotropic hormone receptor
Protein synonyms
hypergonadotropic hypogonadism, LHR, LSH-R, Luteinizing hormone receptor, lutropin/choriogonadotropin receptor
Uniprot ID
Mouse ortholog
Lhcgr (16867)
lutropin-choriogonadotropic hormone receptor (P30730)
Alternate
No data
Variants
No data
Financial
Revenue by drug
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â‚£
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Estimated US medical usage
Lutropin alfa
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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323 adverse events reported
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